NO PROLIFERATIVAS. – Glomerulonefritis de cambios mínimos. – Glomerulosclerosis segmentaria y focal. – Glomerulonefritis membranosa. Clasificación e recursos externos Glomerulopatía ou glomerulite é o termo que define ás diversas doenzas que afectan ao glomérulo renal do nefrón, unha. infantil: importancia de las observaciones microscópicas de luz, inmunofluorescencia y electrones para una correcta clasificación de las glomerulopatías.

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Back to Renal Pathology Volver a Patologia Renal The latter are sometimes very confusing. In these pages a new morfologic approach is presented to diagnose and classify these GPs with CR. Glomerular crescents CRsnecrosis, endothelio mesangial cell proliferation, inflammation, thrombosis and mesangial cell proliferation, sclerosis and fibrosis are complications closely associated and usually superimposed on other glomerulopathies GPs. The same disease may some times have only necrosis, CRs, cell proliferation, inflammation, thrombosis, fibrosis or sclerosis.

Some other times it may have all mentioned lesions in the same biopsy. For didactic reasons, tradition and because there are truly predominating patterns, we have sub divided the group of acute complications in five morphologic patterns: Mesangial cell proliferation predominates MSGL.

These two patterns are easier to identify in the renal biopsy and are discussed elsewhere Link. Here the predominating lesion in the biopsy are crescents. This is the patterns discussed here. Here vasculitis predominates in the biopsy. Here necrosis is the predominating lesion. These two latter patterns are also discussed elsewhere Link. GPs with inflammation allograft glomerulopathy or cell proliferation alone vasculitis are described with the respective glomerulopathies.

It is obvious that overlapping of these patterns is frequently seen in renal biopsies and clinical information becomes crucial for the diagnosis of disease. The study of each complicacion may be approached differently: When studying CRs GL we will also see associations with necrosis, vasculitis, microangiopathies, sclerosis, fibrosis, others.

If the vasculitis are studied, we will also find necrosis, inflammation, crescents, thrombosis sclerosis, fibrosis, others. SL glomerulares, necrosis, trombosis, proliferacion endotelio mesangial, inflamacion, esclerosis y fibrosis, son complicaciones proximamente asociadas y que usualmente se superponen a otras glomerulopatias. Una enfermedad puede algunas veces presentar solamente necrosis, proliferacion celular, inflamacion, SL, trombosis o esclerosis. Pero otras veces la misma enfermedad puede presentar todas estas lesiones en una misma biopsia.

Por razones didacticas, tradicion y por que realmente existen patrones morfologicos predominantes, hemos subdividido el grupo de complicaciones agudas en cinco patrones morfologicos: La proliferacion celular mesangial predomina GLMS. Glomerulitis trombotica micrangiopatica GLTM. La lesion trombotica microangiopatica predomina.


Estos dos patrones morfologicos son mas faciles de identificar y se discuten en otra parte Link.

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Este es el grupo clasifocacion aqui. Aqui prodomina la necrosis. Estos dos ultimos patrones se discuten en otra parte LINK. Las glomerulitis con inflamacion glomerulopatia de trasplante o proliferacion celular solamente vasculitis, necrosis glomerular se describen con las glomerulopatias correspondientes. Es obvio que la superposicion de estos patrones morfologicos es frecuente en las biopsias renales y la informacion clinica completa es crucial para el diagnostico final de enfermedad.

Cada complicacion puede ser enfocada desde diferentes puntos de vista. Si se estudian las GL con SL entre sus subgrupos se encontraran patrones con necrosis, con vasculitis, con microangiopatias tromboticas, con esclerosis y con fibrosis.

Si se estudian las vasculits se encontraran: Rapidly progressive renal insufficiency with oliguria or anuria.

Insuficiancia renal rapidamente progresiva con oliguria o anuria. Diagnostic Glomerular Lesions in figs. Necrosis and fibrin deposition are also frequently found. Tubules, interstitium and blood vessels are usually uninvolved. Necrosis g,omerulopatias segmental y deposicion de fibrina son frecuentes. Tubulos, intersticio y vasos sanguineos usualmente no presentan lesion inflamatoria.

Goodpasture Syndrome if there is involvement of Lungs and Kidney. The names of glomerulopathies in this color are standardized ylomerulopatias proposed in our new morphologic classification. GL is applied to inflammation reactive lesions without immune complex deposits pauci-immune. Sindrome de Goodpasture si hay compromiso de Pulmon y Rinon.

GN anti MBG si solamentes los rinones estan envueltos.

Glomerulopatía – Wikipedia, a enciclopedia libre

GL se aplica a las lesiones inflamatorias reactivas sin complejos inmunes organizados pauci-inmune. Variations of the morphologic pattern: It is obvious that the variations of the morphologic pattern of CRGL are numerous. Focal involvement is seen in early or mild cases. Interstitial nephritis glomerulopaias positive anti TBM is rare. Rarely granulomatous inflammation may be seen in the crescents and interstitium.

Es obvio que las variaciones del patron morfologico de las Glomerulitis con clasifciacion son numerosas. Compromiso focal puede verse en casos glomerulopatisa o tempranos. Nefriris intersticial con anti MBT positiva es raro. Rara vez se ven granulomas glomerulares o intersticiales. CR are usually complications superimposed on other nephropathies. However, CR are also prominent lesions of primary or idiopathic glomerulopathies with or without extra glomerular pathology.

When the pathologist is confronted with the renal biopsy he may see: The sample has crescents and underlying GP.


These underlying GPs may have immune deposits GN ; may have non immune deposits Metabolic GO ; may have only derangement of the glomerular components GD ; or may have other non specific reactive lesions complications GL. Due to the marked distortion produced to the capillary loops, the underlying GP is frequently difficult to recognize and without complete clinical history these cases end with the diagnosis of “Idiopathic Crescentic Glomerulitis”.

The biopsy has CRs but no recognizable GP. TEM clasuficacion negative for deposits. The renal biopsy shows glomerular CRs but no recognizable GP. But there are signs of vasculitis ANCA positiveabcesses or endocarditis. Or, there is no vasculitis Idiopathic.

For more details see chart below and “Glomerulopathies with Crescents”. Semilunas glomerulares usualmente se superponen sobre otras nefropatias. Sinembargo, semilunas son tambien prominentes en glomerulitis primarias Anti MBG o glomerulitis idiopaticas con o sin patologia extraglomerular. La muestra tiene semilunas pero tambien glomerulopatia subyacente que puede ser: Debido a la distorcion marcada del ovillo glomerular la glomerulopatia subyacente is dificil de reconocer.

Sin una historia clasificaciion completa estos casos acaban con el diagnostico de “Glomerulitis con Semilunas Idiopatica”. La muestra tiene semilunas pero no hay glomerulopatia subyacente reconocible. Hay semilunas glomerulares pero no hay gflomerulopatia subyacente. MF y MET son negativos. No hay depositos inmunes, no hay glomerulopatias subyacentes, no hay patron linear, no hay lesiones extraglomerulares.

El diagnostico es de Glomerulitis con Semilunas Idiopopatica. Para mas detalles ver en cuadro de abajo y “Glomerulopatias con Semilunas”. Glomerulopathies With Crescents by Histologic Appearance.

Traditional names are used. The sample has Crescents glomerulpatias Recognizable Underlying Glomerulopathy: CR with Underlying immune complex GN. Cell proliferation, rare necrosis except SLE.

Other lesions according to underlying GP. Ig and C according to underlying GN. Crescents with underlying metabolic diseases. Focal CR variable age. Crescents with Glomerular dysmorphism. Focal CRvariable age. Other lesions according the underlying Glomreulopatias.

Diagnostic Pathology

Malignant FSGS, diabetic nephropathy, Alport’s disease, benign nephrosclerosis, Infantile mesangial sclerosis, Sickle cell glomerulopathy, other 6. Crescents with other Complications Glomerulitis. Glomerular thrombi and thrombotic micro angiopathy.

Ig and C are negative. HUS, Malignant hypertension, anti phospholipid syndrome, scleroderma, cyclosporine toxicity, other. The sample has CRs but no recognizable underlying GP.